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KMID : 0360419830190020017
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Korean Journal of Pharmacology
1983 Volume.19 No. 2 p.17 ~ p.24
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A Study on the Diuretic Action of Buxuletin
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Abstract
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Buxus leaves(Buxus microphylla var. koreana Nakai) have been used as a folk medicine in "treating woman´s disease. The chemical constituents, which have been identified from Buxus sempervirens L. in Europe, are so far known in isolation of buxus alkaloids, cyclobuxine, buxamine, norbuxamine and buxaminol. But But any study on the pharmacological action of Buxus microphylla var. koreana Nakai has not yet been carried out, however, active substances have not been identified. As an attempt to isolate the biologically active substances from this plant, the examination of chemical constituents was undertaken.
In the experiment, the crystalline component (C10H8O4) obtained from Euxus microphylla var. koreana Nakai was identified as a g-methoxy, 7-bydroxy cormarin ly chemical and physical methods. We named this crystal buxuletin.
Therefore, we intended to screen the pharmacological action of buxuletin, especially, its diuretic effects in rabbits. Buxuletin was intraveneously injected to the rabbit in the dose of 20 mg/kg, 10 mg/kg and 5 mg/kg. The variations of urine volume and minerals (Na+, K+ and Cl-) in urine were measured at an interval of 15 minutes for 4 hours after the treatment of buxuletin.
The observed results are as follows:
1) With the administration of buxuletin(20 mg/kg, 10 mg/kg), the remarkable increment of the excreted urine volume was observed during the relatively long period. Excretion rates of urinary minerals(N+, K+ and Cl-) were also increased.
2) In a dose of 5 mg/kg, the slight increment on the diuretic actions of rabbits was observed. From the above results, authors name this crystal buxuletin and buxuletin shows the diuretic action.
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